CRRT and a downward trend in mortality rates
The RENAL1 and ATN2 studies represent a substantial improvement in patient outcomes compared to previous studies over the last 10 years involving patients with similar illness severity.
CRRT and improved renal recovery
The BEST kidney study3 and the SWING study4 were observational analyses comparing the choice of CRRT to IHD for initial treatment of AKI patients.
The BEST kidney study shows:
An 85% renal recovery rate* for patients treated initially with CRRT vs. 66.1% for patients treated at the outset with IRRT. (P<0.0001)
The SWING study indicates:
Cumulative incidence of permanent renal failure was 8.3% in CRRT group vs. 16.5% in the IHD group.**
CRRT and Fluid Overload
In addition, CRRT facilitates fluid overload management, which has been associated with increased mortality in AKI patients. CRRT may also maintain hemodynamic stability in critically ill AKI patients when compared to IRRT.
Now is the right time to consider the expanding body of clinical data that details the benefits of CRRT in treating critically ill AKI patients.
*Results measured in surviving patients at hospital discharge.
**Results measured in surviving patients at 90 days.
- RENAL: Randomized Evaluation of Normal versus Augmented Level of renal replacement. Bellomo et al, Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients. N Engl J Med 2009; 361: 1627-38.
- Palevsky, P M, et al: Intensity of Renal Support in Critically Ill patients with acute kidney injury. (ATN) N Engl J Med 2008; 359, Vol 0.
- Uchino et al: Patient and kidney survival by dialysis modality in critically ill patients with acute kidney injury. The International Journal of Artificial Organs 2007; Vol. 30, No. 4, 281-292.
- Bell, M, et al: Continuous renal replacement therapy is associated with less chronic renal failure than intermittent hemodialysis after acute renal failure. Intensive Care Medicine 2007.
